MOTS-C 40mg

MOTS-C (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial genome. Unlike nuclear-encoded peptides, MOTS-C is translated from mitochondrial RNA and has been investigated for its role in metabolic regulation, cellular stress responses, and inter-organ signalling between mitochondria and the nucleus.

Areas of Interest

Laboratory studies of MOTS-C have investigated a variety of promising areas:

• •Metabolic regulation & energy homeostasis — studied for its effects on glucose metabolism, fatty acid oxidation, and AMPK-related signalling pathways in cellular and animal models.
• •Exercise-mimetic effects — explored for potential influences on physical performance, fatigue resistance, and muscle metabolism in exercise research models.
• •Insulin sensitivity & glucose metabolism — investigated in models of insulin resistance and metabolic stress for effects on glucose uptake and glycaemic control.
• •Mitochondrial-nuclear communication — examined as a signalling peptide that may modulate nuclear gene expression in response to mitochondrial metabolic status.
• •Inflammation & cellular stress — studied for regulatory effects on inflammatory markers and oxidative stress pathways in research settings.

As a research-grade reference material, our MOTS-C is supplied as a lyophilized powder with a purity of ≥99.0% as verified by HPLC and mass spectrometry. Each batch is accompanied by a Certificate of Analysis documenting sequence integrity, molecular weight confirmation, and chromatographic purity.