Name: Ipamorelin
Brand: Hati Peptides
SKU: IPA-10MG
Price: 22.49 GBP
Availability: InStock

Question 1

What is Ipamorelin and how does it work in research models?

Accepted Answer

Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) that functions as a selective growth hormone secretagogue. In research models, it stimulates growth hormone release through the ghrelin receptor (GHS-R1a) without significant stimulation of cortisol, prolactin, or other pituitary hormones. This selectivity makes it valuable for research into isolated GH axis manipulation. The peptide's mechanism involves GHS-R1a activation, increased intracellular calcium, and phospholipase C activity in somatotroph cells.

Question 2

How do I reconstitute Ipamorelin for laboratory use?

Accepted Answer

Reconstitute lyophilised Ipamorelin with bacteriostatic water (0.9% benzyl alcohol). Inject the water slowly down the inside wall of the vial and gently swirl to aid dissolution. The peptide is generally soluble in aqueous solutions. Typical research stock concentrations range from 1–10 mg/mL. Store lyophilised powder at −20°C; reconstituted solution at 2–8°C, protected from light. Solutions are stable for 7–14 days under refrigeration. The D-amino acid substitutions confer some protease resistance, but standard protease inhibitors may be included in incubation media.

Question 3

What purity standard is recommended for Ipamorelin research?

Accepted Answer

Research-grade Ipamorelin should be ≥98% pure by HPLC, with ≥99% being the preferred standard. Mass spectrometry identity confirmation is essential to verify the pentapeptide sequence (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and molecular weight (~711.9 Da). The D-amino acid substitutions should be confirmed by chiral analysis or specific enzymatic digestion. Batch-specific Certificates of Analysis should document purity, identity, and endotoxin levels. The peptide's small size and modifications make analytical verification particularly important.

Question 4

Is Ipamorelin legal for research in the UK?

Accepted Answer

Yes. Ipamorelin is not a controlled substance under the UK Misuse of Drugs Act 1971 and is not scheduled under the Psychoactive Substances Act 2016. It is classified as a research peptide for laboratory use and is not licensed as a medicine by the MHRA. Research institutions should ensure compliance with institutional ethics approvals and standard laboratory safety protocols.

Question 5

What cellular models are used for Ipamorelin research?

Accepted Answer

Standard cellular models include: (1) primary pituitary cells and GH3 cells for GH secretion and selectivity studies; (2) transfected cell lines expressing GHS-R1a for receptor binding and signalling; (3) 3T3-L1 adipocytes for lipolysis and adipokine studies; (4) primary hepatocytes for IGF-1 production; and (5) C2C12 myotubes for protein synthesis studies. Researchers compare Ipamorelin to GHRP-2 and GHRP-6 to examine selectivity differences in pituitary hormone secretion.

Quantity	Discount	Price each
2	5%	£21.37
3	7%	£20.92
4+	10%	£20.24

Ipamorelin

Ipamorelin

Research Overview

Areas of Interest

Technical Specifications

Certificate of Analysis