Name: Selank
Brand: Hati Peptides
SKU: SELANK-10MG
Price: 17.1 GBP
Availability: OutOfStock

Question 1

What is Selank and how does it work in research models?

Accepted Answer

Selank is a synthetic 7-amino-acid heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) designed as a stable analogue of tuftsin, a natural immunomodulatory peptide. In research models, it operates through multiple mechanisms: modulation of neuroimmune mediator production (cytokines, chemokines), upregulation of BDNF expression in neuronal cultures, effects on GABAergic neurotransmission, potential inhibition of enkephalin-degrading enzymes, and modulation of serotonin metabolism. The peptide's neuroimmune modulation is studied in glial cell cultures, while its anxiolytic effects are examined in neuronal stress-response models.

Question 2

How do I reconstitute Selank for laboratory use?

Accepted Answer

Reconstitute lyophilised Selank with bacteriostatic water (0.9% benzyl alcohol). Inject the water slowly down the inside wall of the vial and gently swirl to aid dissolution. The peptide is generally soluble in aqueous solutions. Typical research stock concentrations range from 1–10 mg/mL. Store lyophilised powder at −20°C; reconstituted solution at 2–8°C, protected from light. Solutions are stable for 7–14 days under refrigeration. The peptide's small size may result in non-specific binding to plastic surfaces; pre-wetting tubes with BSA-containing buffer may reduce peptide loss.

Question 3

What purity standard is recommended for Selank research?

Accepted Answer

Research-grade Selank should be ≥98% pure by HPLC, with ≥99% being the preferred standard. Mass spectrometry identity confirmation is essential to verify the 7-amino-acid sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro) and molecular weight (~751.9 Da). The synthetic modifications should be confirmed by chromatographic and mass spectrometric analysis. Batch-specific Certificates of Analysis should document purity, identity, and endotoxin levels. Given the peptide's small size, mass spectrometry is particularly important for confirming sequence integrity.

Question 4

Is Selank legal for research in the UK?

Accepted Answer

Yes. Selank is not a controlled substance under the UK Misuse of Drugs Act 1971 and is not scheduled under the Psychoactive Substances Act 2016. It is classified as a research peptide for laboratory use and is not licensed as a medicine by the MHRA. Research institutions should ensure compliance with institutional ethics approvals and standard laboratory safety protocols.

Question 5

What cellular models are used for Selank research?

Accepted Answer

Standard cellular models include: (1) primary cortical and hippocampal neuronal cultures for viability and morphology studies; (2) astrocyte and microglial cultures for neuroimmune mediator production; (3) BDNF expression assays using qPCR and Western blot; (4) GABAergic interneuron cultures for inhibitory neurotransmission studies; (5) stress-response models using corticosterone or oxidative stress; and (6) brain slice models for electrophysiological recordings. Researchers compare Selank to tuftsin and semax in comparative studies.

Selank

Research Overview

Areas of Interest

Technical Specifications

Certificate of Analysis